Anti-Nogo-A軸索過度生長抑制因子-A抗體相關(guān)標(biāo)記     Alexa Fluor 350   Alexa Fluor 488   Alexa Fluor 555   Alexa Fluor 647   AP   APC   Biotin  Cy3   Cy5  
Cy5.5   Cy7   FITC   Gold   HRP   PE   PE-Cy3   PE-CY5   PE-CY5.5   PE-CY7   RBITC  
英文名稱     Anti-Nogo-A
中文名稱     軸索過度生長抑制因子-A抗體
別    名     Nogo A; ASY; Foocen; Human NogoA; KIAA0886; My043 protein; Nbla00271; Nbla10545; Neurite growth inhibitor 220; Neurite Outgrowth Inhibitor; Neuroendocrine specific protein; Neuroendocrine specific protein C homolog; NI220/250; Nogo A; NOGO; Nogo protein; NogoA; NSP; NSP CL; Reticulon 4; Reticulon 5; Reticulon4; Reticulon5; RTN 4; RTN 4A; RTN X; RTN xL; RTN4 A; RTN4; RTN4 B1; RTN4 B2; RTN4 C; RTN4 protein; RTN4_HUMAN; Reticulon-4; Neuroendocrine-specific protein. 
濃    度     1mg/1ml
抗體來源     Rabbit
克隆類型     polyclonal
交叉反應(yīng)     Human, Mouse, Rat, 
產(chǎn)品類型     一抗  
研究領(lǐng)域     細(xì)胞生物 神經(jīng)生物學(xué)
蛋白分子量     predicted molecular weight: 131kDa
性    狀     Lyophilized or Liquid
免 疫 原     KLH conjugated synthetic peptide derived from human RTN4 protein
亞    型     IgG
純化方法     affinity purified by Protein A
儲 存 液     0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
Anti-Nogo-A軸索過度生長抑制因子-A抗體產(chǎn)品應(yīng)用      WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 
（石蠟切片需做抗原修復(fù)） 

 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.
保存條件     Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note     This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹    This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.
Function : Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
Subunit : Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3 interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1.
Subcellular Location : Endoplasmic reticulum membrane. Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.
Tissue Specificity : Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific.
Similarity : Contains 1 reticulon domain.
Database links :
Entrez Gene: 57142 Human
Entrez Gene: 68585 Mouse
Entrez Gene: 83765 Rat
Omim: 604475 Human
SwissProt: Q9NQC3 Human
SwissProt: Q99P72 Mouse
SwissProt: Q9JK11 Rat
Unigene: 704007 Human

神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology）
Nogo-A軸索生長抑制因子在中樞神經(jīng)的髓鞘上表達(dá)并在抑制損傷軸索修復(fù)中起著關(guān)鍵作用，從而有限制神經(jīng)功能恢復(fù)的現(xiàn)象。主要定位細(xì)胞核。
產(chǎn)品圖片