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Rantes Human/重組人趨化因子（CCL5）

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產(chǎn)品簡介

Rantes Human/重組人趨化因子（CCL5）產(chǎn)品編號：CHM-328
產(chǎn)品規(guī)格：5μg/20μg/1mg

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Rantes Human/重組人趨化因子（CCL5）

產(chǎn)品編號：CHM-328
產(chǎn)品規(guī)格：5μg/20μg/1mg

Synonyms	Small inducible cytokine A5, CCL5, T-cell-specific RANTES protein, SIS-delta, T cell- specific protein P228, TCP228, chemokine （C-C motif） ligand 5, SISd, SCYA5, RANTES, D17S136E, MGC17164.
Introduction	Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. It has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines （i.e. IL-2 and IFN-?） that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer （NK） cells to form CHAK （CC-Chemokine-activated killer） cells. It is also a HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans.
Description	Rantes Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 68 amino acids and having a molecular mass of 7809.2 Dalton. The Rantes is purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered White lyophilized （freeze-dried） powder.
Formulation	The Rantes was lyophilized from a concentrated （1mg/ml） solution in water containing no additives.
Solubility	It is recommended to reconstitute the lyophilized Rantes in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Stability	Lyophilized Rantes although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL5 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
Purity	Greater than 98.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE.
Amino acid sequence	The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Pro-Tyr-Ser-Ser.
Biological Activity	The activity is determined by the chemoattract of human blood monocytes at a concentration between 1-10 ng/ml.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.