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重組人成纖維細(xì)胞生長(zhǎng)因子12/FGF12 Human

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重組人成纖維細(xì)胞生長(zhǎng)因子12/FGF12 Human 產(chǎn)品編號(hào)：CYT-620
產(chǎn)品規(guī)格：2μg/10μg/1mg

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重組人成纖維細(xì)胞生長(zhǎng)因子12/FGF12 Human

產(chǎn)品編號(hào)：CYT-620
產(chǎn)品規(guī)格：2μg/10μg/1mg
 

Catalogue Number CYT-620
Synonyms FGF-12, FGF12, FGF12B, FHF1, Fibroblast growth factor 12, Fibroblast growth factor homologous factor 1, FHF-1, Myocyte-activating factor.
Introduction FGF12 is part of the Fibroblast Growth Factor （FGF） family which has a vast mitogenic and cell survival functions, and play a role in a range of biological activities, among them are embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF-12 doesn’t obtain the N-terminal signal sequence present in the majority of the FGF family members, but it contains clusters of basic residues that act as a nuclear localization signal. When transfected into mammalian cells, FGF12 accumulated in the nucleus, but was not secreted. FGF12 is involved in nervous system development and function. FGF12 binds to IB2 （islet brain-2）, a cellular kinase scaffold, and voltage gated sodium channels and is also involved in intracellular signaling and ion exchange.
Description The FGF-12 Human recombinant protein is a single, non-glycosylated polypeptide chain produced in E. coli, having a molecular weight of 22.6kDa and containing 201 amino acids （1-181）. The FGF12 is fused to a 20 amino acid His tag at the N-terminus.
Source Escherichia Coli.
Formulation The FGF-12 solution （1mg/ml） contains 20mM Tris pH-7.5, 1mM DTT, 2mM EDTA and 10% glycerol.
Storage Store FGF12 at -20°C. Can be stored at 4°C for a limited period of time of 7 days.
Purity Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence MSSHHHHHH SSGLVPRGSH MESKEPQLKG IVTRLFSG YFLQMHPDGT IDGTKDENSD YTLFNL*G LRVVAIQGVK ASLYVAMNGE YLYSSDVFT PECKFKESVF ENYYVIYSST LYRESGRA WFLGLNKEGQ IMKGNRVKKT KPSSHFVPKP IEVCMYREQS LHEIGEKQGR RKSSGTPTM NGGKVVNQDS T.
Usage ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.


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