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A0168L-肌肽/N-β-丙氨酰-L-組氨酸/β-氨基-L-丙酰組氨酸/L-Carnosine
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產(chǎn)品簡(jiǎn)介
Amino Acid Sequence: β-Ala-His
CAS Number: 305-84-0
Linear Formula: C9H14N4O3
Molecular Weight: 226.23
Beilstein Registry Number: 87671
EC Number: 206-169-9
產(chǎn)品介紹
Description
Biochem/physiol Actions Dipeptide with potent antioxidant and antiglycation activity; blocks nonenzymatic glycosylation and protein cross-linking induced by reactive aldehydes.
L-Carosine is a dipeptide found at millimolar concentration in brain, muscle and the lens of the eye. In model systems it is a potent antioxidant that scavenges oxygen free radicals and transition metal ions. It blocks protein-protein and protein-DNA cross-links induced by hypochlorite anions and toxic aldehydes such as acetaldehyde, formaldehyde, and malondialdehyde, the primary product of lipid peroxidation. It also inhibits nonenzymatic protein glycation induced by aldose and ketose reducing sugars and inhibits the formation of toxic advanced glycation end products （AGE）. These activities make it of interest in studies of aging, atherosclerosis, Alzheimer′s disease, and the secondary effects of diabetes.
Properties
assay ~99%
form crystalline
mp 253 °C （dec.）（lit.）
Gene Information human ... CA1（759）, CA2（760）
storage temp. −20°C
Safety
Personal Protective Equipment Eyeshields, Gloves, type N95 （US）, type P1 （EN143） respirator filter
WGK Germany 2
RTECS MS3080000
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