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Anti-phospho-HDAC7 (Ser318)磷酸化組蛋白去乙?;?抗體

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Anti-phospho-HDAC7 (Ser318)磷酸化組蛋白去乙?;?抗體

詳細介紹

Anti-phospho-HDAC7 (Ser318)磷酸化組蛋白去乙?;?抗體

專業(yè)提供Anti-phospho-HDAC7 (Ser318)磷酸化組蛋白去乙酰化酶7抗體,廣泛應(yīng)用于免疫組化,ELISA,Western Blot  IHC-F(免疫組化-冰凍切片),IHC-P (免疫組化-石蠟切片)IP(免疫沉淀), Flow-Cyt等方面。 

抗體交叉反應(yīng)的原因:
指抗體除與其相應(yīng)的抗原發(fā)生特異性反應(yīng)外還與其它抗原發(fā)生反應(yīng)。產(chǎn)生的原因有以下幾個方面:
1. 抗原特異性指用于免疫動物的抗原性物質(zhì)中含有多種抗原分子,它引起動物產(chǎn)生針對多種抗原分子特異性的相應(yīng)抗體。任何其它物質(zhì)只要含有一種或多種與上述物質(zhì)相同的抗原分子,必將與上述多特異性的抗血清發(fā)生交叉反應(yīng)。
2. 共同決定簇即兩種抗原分子中都含有相同的抗原決定簇。
3. 決定簇相似,兩種不同的抗原決定簇,如果結(jié)構(gòu)大致相同,由于空間構(gòu)象關(guān)系,某一決定簇的相應(yīng)抗體可以與大致相同的決定簇發(fā)生交叉反應(yīng)。當然抗原一抗體之間構(gòu)象相似時的結(jié)合力小于吻合時的結(jié)合力。

產(chǎn)品詳細信息:
產(chǎn)品編號  Rs-3216R
英文名稱  Anti-phospho-HDAC7 (Ser318)
中文名稱  磷酸化組蛋白去乙?;?抗體

抗體介紹:HDAC7 is a member of the class II mammalian histone deacetylases, which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. It is an active component of different transcriptional corepressor complexes that can be recruited to specific promoter regions via interactions with a growing number of sequence specific transcriptional factors. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, leading to the inhibition of gene transcription.
別    名  HD 7a; HD7a; HDAC 7; HDAC 7A; HDAC7; HDAC7A; Histone deacetylase 7; Histone deacetylase 7A; 
產(chǎn)品類型  一抗 磷酸化抗體 
抗體來源  Rabbit 
克隆號  Polyclonal
交叉反應(yīng)  hu, rat, mo
蛋白分子量  Predicted Molecular Weight: 31kDa
性狀  Lyophilized or Liquid
濃度  1mg/1ml
免疫原  KLH conjugated Synthesised phosphopeptide derived from human HDAC7 around the phosphorylation site of Ser318
亞型  IgG
純化方法  affinity purified by Protein A
儲存液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用  WB=1:100-500 Elisa=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1/20-1/100
(石蠟切片需做抗原修復(fù))Not yet tested in other applications.
 Optimal dilutions/concentrations should be determined by the end user. 
研究領(lǐng)域  腫瘤 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 細胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 
保存  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

公司提供的.已被國內(nèi)外廣大科研工作者使用,廣泛用于分子生物學(xué)、免疫學(xué)等試驗中。

相關(guān)產(chǎn)品:
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Anti-CK20(Cytokeratin 20)   細胞角蛋白20抗體
Anti-CK1/8/19 (Cytokeratin1/8/19; Keratin 1/8/19)   細胞角蛋白1/8/19抗體
Anti-CK2(Cytokeratin 2; KRT2B; keratin 76)   細胞角蛋白2抗體
Anti-CK4 (Cytokeratin 4)   細胞角蛋白4抗體
Anti-CK5 (Cytokeratin 5)   細胞角蛋白5抗體
Anti-CK5 (Cytokeratin 5)   細胞角蛋白5抗體
Anti-CK7 (Cytokeratin 7)human   抗細胞角蛋白7抗體
Anti-CK7 (Cytokeratin 7)ret mouse   抗細胞角蛋白7抗體(大、小鼠)


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