FITC標(biāo)記的血管緊張素Ⅱ-1型受體抗體是我司為您提供的高品質(zhì)抗體，公司生產(chǎn)的每一個(gè)抗體都經(jīng)過嚴(yán)格檢測(cè)和穩(wěn)定性測(cè)試，保證了結(jié)果的準(zhǔn)確性、敏感性、特異性。公司產(chǎn)品質(zhì)量有保證，*且我司擁有完善的市場(chǎng)營(yíng)銷體系、現(xiàn)代化管理體系和專業(yè)化物流配送系統(tǒng)，zui大程度滿足國(guó)內(nèi)外生命科研人員的產(chǎn)品需求，公司現(xiàn)經(jīng)營(yíng)抗體、ELISA試劑盒、標(biāo)準(zhǔn)品、染色液、染色試劑盒、培養(yǎng)基等多種科研產(chǎn)品，歡迎前來(lái)選購(gòu)！
英文名稱 Anti- Angiotensin II Type 1 Receptor/FITC
中文名稱 FITC標(biāo)記的血管緊張素Ⅱ-1型受體抗體
別 名 AG2S; Agtr 1; Agtr1; Agtr1a; AGTR1B; Angiotensin II receptor type 1; Angiotensin II type 1 receptor; AT-1B; AT-1r; AT1; At1a; AT1AR; AT1B; AT1BR; AT2R1; AT2R1A; AT2R1B; HAT1R; Type 1 angiotensin II receptor; AGTR1_HUMAN; Type-1 angiotensin II receptor; Angiotensin II type-1 receptor; AT1R; Ang II; Angiotensin II receptor type 1; Angiotensin II type 1 receptor; Angiotensin receptor 1; Angiotensin receptor 1B; AT 1B; AT1; AT1R.  
說(shuō) 明 書 100ug  
研究領(lǐng)域 心血管  生長(zhǎng)因子和激素  新陳代謝  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Cow, Rabbit, 
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性 狀 Lyophilized or Liquid
濃 度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human AT1R
亞 型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq].

Function:
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subunit:
Interacts with MAS1 (Probable). Interacts with ARRB1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Liver, lung, adrenal and adrenocortical adenomas.

Post-translational modifications:
C-terminal Ser or Thr residues may be phosphorylated.

DISEASE:
Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 185 Human

Entrez Gene: 11607 Mouse

Entrez Gene: 11608 Mouse

Entrez Gene: 24180 Rat

Entrez Gene: 81638 Rat

Omim: 106165 Human

SwissProt: P30556 Human

SwissProt: P29754 Mouse

SwissProt: P29755 Mouse

SwissProt: P25095 Rat

SwissProt: P29089 Rat

Unigene: 477887 Human

Unigene: 728754 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

AT1-受體：血管緊張素Ⅱ-1型受體抗體,主要用于心血管病方面的研究。