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英文名稱 Anti-A4GNT/FITC
中文名稱 FITC標記的α1,4-N-乙酰葡糖胺轉(zhuǎn)移酶α4Gn-T抗體
別 名 4-N-acetylglucosaminyltransferase; A4GCT_HUMAN; A4GNT; Alpha 1 4 N acetylglucosaminyltransferase; Alpha-1; Alpha4GnT; EC 2.4.1.; MGC149493. 
說 明 書 100ug  
研究領(lǐng)域 腫瘤  細胞生物  信號轉(zhuǎn)導  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, 
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
細胞定位 細胞膜 
性 狀 Lyophilized or Liquid
濃 度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human A4GNT (131-180aa)
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
FITC標記的α1,4-N-乙酰葡糖胺轉(zhuǎn)移酶α4Gn-T抗體保存條件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
FITC標記的α1,4-N-乙酰葡糖胺轉(zhuǎn)移酶α4Gn-T抗體產(chǎn)品介紹 background:
Alpha 1,4-N-acetylflucosaminyltransferase (Alpha4Gn-T) mediates the biosynthesis of mucin type glycoprotein (O-glycan). Alpha4Gn-T acts as the key enzyme for the formation of the unique glycan GlcNAcalpha1-4Galbeta1-R, and most efficiently transfers N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. Alpha4Gn-T is a single-pass type II membrane protein associated with the Golgi apparatus and contains the conserved DXD motif involved in catalytic activity. It is expressed in stomach and pancreas, as well as in gastric cancer cells. Alpha4Gn-T is not expressed in peripheral blood cells, making it a useful biomarker for pancreatic cancer. Alpha4Gn-T and Mucin 6 expression is upregulated in the gastric mucosa of H.pylori infected patients, which suggest the involvement of ?Gn-T in defense against H. pylori infection.

Function:
Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans.

Subcellular Location:
Golgi apparatus membrane.

Tissue Specificity:
Detected in stomach and pancreas.

Similarity:
Belongs to the glycosyltransferase 32 family.

Database links:
UniProtKB/Swiss-Prot: Q9UNA3.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.